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21 U.S. Code § 360eee / GS1 EPCIS <3ms Edge Edge Compute

GS1 Verification Router Service (VRS) Lightweight Messaging Spec

GS1 Verification Router Service (VRS) protocol engine for automated saleable drug returns verification in under 5ms. This specification documents the exact field layout, checksum rules, and validation behavior so your integration matches 21 U.S. Code § 360eee / GS1 EPCIS without reading the source standard.

Latency: <3ms Edge Availability: 99.99% Standard: GS1 VRS 1.3 / FDA DSCSA In-Memory Execution
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input.txt 0 B
output.json demo-ready
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{
  "status": "Click RUN VALIDATION to execute on the Cloudflare edge..."
}
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Prompt-Ready Specification for AI Agents llms.txt
Structured format rules and schemas optimized for LLM coding agents and Model Context Protocol tooling.
Raw .md
Official Standard & Validation Protocol Authority: U.S. Food & Drug Administration (FDA) DSCSA ↗

Quick Summary: GS1 Verification Router Service (VRS) protocol engine for automated saleable drug returns verification in under 5ms. Validates strictly against 21 U.S. Code § 360eee / GS1 EPCIS with sub-5ms in-memory response times.

Latency
<3ms Edge
Standard
GS1 VRS 1.3 / FDA DSCSA
Version
Max Payload
512 KB
Privacy
In-Memory (0 bytes stored)

Specification & Structural Breakdown

Technical Summary: Validates strictly against 21 U.S. Code § 360eee / GS1 EPCIS. Payloads are parsed in memory and return clean, typed JSON in milliseconds with zero data logged.

Under DSCSA Section 582, wholesale distributors must verify the product identifier (GTIN, SN, Lot, Exp) with the manufacturer prior to redistributing returned drug packages.

The GS1 Lightweight Messaging Standard for VRS defines standard RESTful JSON request and response payloads exchanged via secure routing lookups.

JSON AttributeTypeDescriptionValidation Rule
gtinString (14 digits)Global Trade Item NumberValid Modulo-10 checksum
serialNumberString (1-20 chars)Unique Serial IdentifierAlphanumeric regex: ^[A-Za-z0-9-._]{1,20}$
expirationDateString (YYMMDD / ISO)Product Expiration DateValid date format
lotNumberString (1-20 chars)Manufacturing Batch CodeAlphanumeric identifier

Parsed JSON Response Model

The edge microservice transforms input payloads into strongly-typed hierarchical JSON envelopes with sub-5ms latency:

HTTP 200 JSON Response Envelope
{
  "vrsRequest": {
    "gtin": "00301234567896",
    "serialNumber": "123456789012",
    "expirationDate": "260831",
    "lotNumber": "LOT99881"
  },
  "vrsResponse": {
    "verificationResult": "SUCCESS",
    "verified": true,
    "timestamp": "2026-08-30T12:00:00Z"
  }
}

Copy-Paste Integration Code (6 Languages)

Integrate GS1 Verification Router Service (VRS) Lightweight Messaging Spec directly into your production application with native, zero-dependency code snippets in cURL, Node.js, Python, Go, C#, and a ready-to-paste Claude prompt. Get a free API key → (no credit card required):

curl --request POST \
  --url "https://api.stanzaapi.com/pharma-dscsa/api/v1/dscsa/validate-barcode" \
  --header "Content-Type: application/json" \
  --header "x-api-key: YOUR_API_KEY" \
  --data '{
  "rawBarcode": "010030123456789621123456789012\u001d1726083110LOT99881"
}'
const response = await fetch("https://api.stanzaapi.com/pharma-dscsa/api/v1/dscsa/validate-barcode", {
  method: "POST",
  headers: {
    "Content-Type": "application/json",
    "x-api-key": process.env.API_KEY || "YOUR_API_KEY"
  },
  body: JSON.stringify({
  "rawBarcode": "010030123456789621123456789012\u001d1726083110LOT99881"
})
});

const data = await response.json();
console.log(data);
import requests
import json

url = "https://api.stanzaapi.com/pharma-dscsa/api/v1/dscsa/validate-barcode"
headers = {
    "Content-Type": "application/json",
    "x-api-key": "YOUR_API_KEY"
}
payload = {
    "rawBarcode": "010030123456789621123456789012\u001d1726083110LOT99881"
}

response = requests.post(url, json=payload, headers=headers)
print(response.json())
package main

import (
	"bytes"
	"fmt"
	"io"
	"net/http"
	"os"
)

func main() {
	url := "https://api.stanzaapi.com/pharma-dscsa/api/v1/dscsa/validate-barcode"
	payload := []byte(`{"rawBarcode":"010030123456789621123456789012\u001d1726083110LOT99881"}`)

	req, _ := http.NewRequest("POST", url, bytes.NewBuffer(payload))
	req.Header.Add("Content-Type", "application/json")
	req.Header.Add("x-api-key", os.Getenv("API_KEY"))

	res, err := http.DefaultClient.Do(req)
	if err != nil {
		panic(err)
	}
	defer res.Body.Close()
	body, _ := io.ReadAll(res.Body)
	fmt.Println(string(body))
}
using System;
using System.Net.Http;
using System.Text;
using System.Threading.Tasks;

class Program
{
    static async Task Main()
    {
        using var client = new HttpClient();
        client.DefaultRequestHeaders.Add("x-api-key", Environment.GetEnvironmentVariable("API_KEY") ?? "YOUR_API_KEY");

        var json = @"{""rawBarcode"":""010030123456789621123456789012\u001d1726083110LOT99881""}";
        var payload = new StringContent(json, Encoding.UTF8, "application/json");

        var response = await client.PostAsync("https://api.stanzaapi.com/pharma-dscsa/api/v1/dscsa/validate-barcode", payload);
        var content = await response.Content.ReadAsStringAsync();
        Console.WriteLine(content);
    }
}
Integrate the StanzaAPI pharma-dscsa micro-API.

Endpoint: POST https://api.stanzaapi.com/pharma-dscsa/api/v1/dscsa/validate-barcode
Auth header: x-api-key: YOUR_API_KEY
Content-Type: application/json
Request body:
{
  "rawBarcode": "010030123456789621123456789012\u001d1726083110LOT99881"
}

Rules:
- Send the request with a 2-second timeout.
- Parse the standard envelope { success, data, meta: { latency_ms, version } }.
- On failure, read { success: false, error, code } and branch on the code.
- Do not retry 4xx responses; surface the error code to the caller.
- Treat invalid-but-well-formed payloads as HTTP 200 with data.valid === false.

Frequently Asked Questions & Technical Notes

What is the required response time for a DSCSA VRS verification request?

Industry standards mandate sub-second response times, and our edge-based engine resolves verification parsing in <5ms.

Related FDA DSCSA & EU FMD Prescription Drug Serialization API Formats

Explore sibling specifications and standards in the same developer cluster:

Complementary Enterprise APIs

Seamlessly orchestrate data pipelines across adjacent financial, regulatory, and supply-chain protocols:

All FDA DSCSA & EU FMD Prescription Drug Serialization API Formats & Specifications (6) Directory Index ↓
GS1 Verification Router Service (VRS) Lightweight Messaging Spec EPCIS 1.2 XML Event Parser & Schema Validator (FDA DSCSA) EPCIS 2.0 JSON-LD Supply Chain Event Parser & Validator FDA 21 CFR 201.25 Barcode Requirement & 2D DataMatrix Spec DSCSA 4-Element 2D DataMatrix Barcode & Matrix Specification DSCSA Section 582 Suspect Product Quarantine & Verification Rules